Theresulting loss of proteostasis, the process by which the health of a cell's proteins is monitored and maintained, is associated with a wide range of age-related humandiseases. Costa-Mattioli and Walter review theintegratedstressresponse(ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis.
Here, we highlight how theintegratedstressresponse(ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis rates, impedes the formation of long-term memory.
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Theintegratedstressresponse(ISR) is a conserved network in eukaryotic cells that mediates adaptiveresponsestodiverse stressors. The ISR pathway ensures cell survival and homeostasis by regulating protein synthesis inresponsetointernal or external stresses. In recent years, the ISR has emerged as an important regulator of the central nervous system (CNS) development, homeostasis and ...
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Protein quality control is essential for the proper function of cells and the organisms that they make up. The resulting loss of proteostasis, the processes by which the health of the cell's proteins is monitored and maintained at homeostasis, is associated with a wide range of age-related humandiseases. Here, we highlight how theintegratedstressresponse(ISR), a central signaling ...
Introduction Theintegratedstressresponse(ISR) is an evolutionarily conservedmechanismtocellularstressthat is activated by different intrinsic and extrinsic factors. The main function of the ISR is to maintain cellular homeostasis by downregulating protein synthesis and upregulating specific target genes [1].
