However, recent work suggests that there is sufficient expression ofGLP-1r on α-cellsfor direct regulation as well. Although the predominant source of circulatingGLP-1is the intestine, the α-cellbecomes a source ofGLP-1when theisletis metabolically stressed.
Glucagon-like peptide1(GLP-1), a proglucagon derivative secreted by gut L-cells in response to meals, acutely enhances glucose-induced insulin secretion inpancreaticisletβ-cells. The dependence of the insulinotropic effect on blood glucose and the lack of adverse cardiac outcomes [1] won the compound a solid reputation among type 2 diabetes mellitus (T2DM) therapeutics, which was further ...
GLP-1and GIP promote insulin secretion directly but also inhibit glucagon and stimulate beta-cellprosurvival and proliferation mechanisms to maintainisletcellmass. 21,24GLP-1also slows ...
Proglucagon can be processed to glucagon-like peptide1 (GLP-1) within theislet, but its contribution toisletfunction in humans remains unknown. We sought to understand whetherpancreaticGLP-1altersisletfunction in humans and whether this is affected ...
Apoptosis plays an important role in the normal physiology of the pancreas, the pathogenesis of dia-betes mellitus (DM) and the success rate ofislettrans-plantation. Glucagon-like peptide-1 (GLP-1), an incretin hormone with multiple effects on glucose metabolism andpancreaticgene expression, has recently been found to have antiapoptotic properties. This new property ofGLP-1has clinical ...
Such details provide a deeper understanding and appreciation for Inferior Pancreatic Islet Cell Failure After Glp 1.
This study was designed to investigatepancreaticisletβ- and α-cellresponsiveness to acute administration of eitherGLP-1or GIP in PI-CF. Research Design and Methods Participants All participants were aged ≥18 years and had completed a 75-g oral glucose tolerance test (OGTT) within 6 months prior to enrollment.
