Complete guide to VitaminB12(cobalamin) (VitaminB12(cobalamin)) forguineapigs. Learn about uses, dosage, side effects, drug interactions, and safety information for this cavy medication.
ABSTRACT The percutaneous absorption of vitaminB12by the rat andguineapigwas investigated. Growth experiments in weanling rats indicated that the vitamin was efficiently absorbed in an active form. Studies with $7Co-labeled cyanocobalamin dem- onstrated that absorption was more efficient from an ethanol solution than from water or dimethyl sulfoxide and was independent of the quantity of ...
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These results indicate the suitability of using isolatedguineapigvillous and crypt cells to examine transport processess of molecules that involve specialized mechanisms. The results also demonstrate that the undifferentiated crypt cell lacks specific transport processes necessary for the active absorption of cobalamin and taurocholate.
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[Studies on experimentally induced vitaminB12deficiency. IV. Histological observations on vitamin-deficientguineapigs].
The thought that colchicine treatment may decrease the absorption ofB12by ileal mucosa was entertained some 50 years ago [98]. In another study, colchicine has reduced the quantity of the receptor for the intrinsic factor-B12complex in the intestinal mucosa ofguineapigs[99], but the dose required was 10-fold higher than the dose used for FMF treatment. The role of colchicine in causing ...
Folic aciddeficiencycan be induced in theguineapigby simple dietarydeficiencywithout the use of intestinal antiseptics (Woolley and Sprince, 1945; Woodruff et al., 1953; Reid et al., 1956). The hematocrit is reduced from a normal level of 40% to 30-35% shortly before death, and the hemoglobin levels drop from a normal level of 14% to 10%.
